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Index > Protein center > AIF1(Gene name) > Human
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  • AIF1 (Gene name),
  • Allograft inflammatory factor 1 (Protein name ),  AIF1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    AIF1(G1;IBA1);
    Protein name:
    Allograft inflammatory factor 1(AIF-1);
    Alternative:
    Protein G1;Ionized calcium-binding adapter molecule 1;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer (Potential). Monomer. Interacts with LCP1.
    Function:
    Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation.
    Subcellular Location:
    Cytoplasm cytoskeleton Cell projection ruffle membrane Peripheral membrane protein Cytoplasmic side Associated with the actin cytoskeleton at membrane ruffles and at sites of phagocytosis.
    Protein Attributes:
    Sequence length:
    147
    Sequence:
    50:
    MSQTRDLQGG | KAFGLLKAQQ | EERLDEINKQ | FLDDPKYSSD | EDLPSKLEGF | 
    100:
    KEKYMEFDLN | GNGDIDIMSL | KRMLEKLGVP | KTHLELKKLI | GEVSSGSGET | 
    147:
    FSYPDFLRMM | LGKRSAILKM | ILMYEEKARE | KEKPTGPPAK | KAISELP
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    MIM:
    SMR:
    KEGG:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human AIF-1
    Cat.:
    E1251h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human AIF-1
    Cat.:
    E1251m
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    Packing:
    96T
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    ELISA Kit for Human AIF-1
    Cat.:
    E1251r
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    Packing:
    96T
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    ELISA Kit for Human AIF-1
    Cat.:
    E1251b
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    Packing:
    96T
    ELISA Kit for Human AIF-1
    Cat.:
    E1251p
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    Packing:
    96T
    CLIA Kit for Human AIF-1
    Cat.:
    U1251h
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human AIF-1
    Cat.:
    U1251r
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human AIF-1
    Cat.:
    U1251b
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human AIF-1
    Cat.:
    U1251p
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human AIF-1
    Cat.:
    U1251m
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human AIF-1
    Polyclonal Antibody for Human AIF-1
    Cat.:
    P1251Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human AIF-1
    Polyclonal Antibody for Human AIF-1
    Cat.:
    P1251Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human AIF-1
    Cat.:
    P1251Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human AIF-1
    Monoclonal Antibody for Human AIF-1
    Monoclonal Antibody for Human AIF-1
    Monoclonal Antibody for Human AIF-1
    Monoclonal Antibody for Human AIF-1
    Protein for Human AIF-1
    Protein for Human AIF-1
    Protein for Human AIF-1
    Protein for Human AIF-1
    Protein for Human AIF-1

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    References
    1. 1.
      "Characterization of a novel gene in the human major histocompatibility complex that encodes a potential new member of the I kappa B family of proteins."
      Albertella M.R. , Campbell D.R.
      Hum. Mol. Genet.3:793-799(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];ALTERNATIVE SPLICING (ISOFORMS 1; 2 AND 3)
    2. 2.
      "Cloning and genomic characterization of LST1: a new gene in the human TNF region."
      Holzinger I. , de Baey A. , Messer G. , Kick G. , Zwierzina H. , Weiss E.H.
      Immunogenetics42:315-322(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1; 2 AND 3)
    3. 3.
      "cDNA cloning of human allograft inflammatory factor-1: tissue distribution, cytokine induction, and mRNA expression in injured rat carotid arteries."
      Autieri M.V.
      Biochem. Biophys. Res. Commun.228:29-37(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3)
      tissue: Lymphocyte.
    4. 4.
      "Allograft inflammatory factory-1. A cytokine-responsive macrophage molecule expressed in transplanted human hearts."
      Utans U. , Quist W.C. , McManus B.M. , Wilson J.E. , Arceci R.J. , Wallace A.F. , Russell M.E.
      Transplantation61:1387-1392(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    5. 5.
      "Complex expression pattern of the TNF region gene LST1 through differential regulation, initiation, and alternative splicing."
      de Baey A. , Fellerhoff B. , Maier S. , Martinozzi S. , Weidle U. , Weiss E.H.
      Genomics45:591-600(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1; 2 AND 3);ALTERNATIVE SPLICING
    6. 6.
      "A new member of the Ig superfamily and a V-ATPase G subunit are among the predicted products of novel genes close to the TNF locus in the human MHC."
      Neville M.J. , Campbell R.D.
      J. Immunol.162:4745-4754(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1; 2 AND 3)
    7. 7.
      "Novel calcium binding protein, Iba1 (ionized calcium binding adapter molecule 1), which is phosphorylated on serine."
      Imai Y. , Ohsawa K. , Kohsaka S.
      Submitted (1996-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)
    8. 8.
      "Upregulation of Allograft inflammatory factor (AIF) is induced by Ab-stimulation in vitro and in human Alzheimer's disease brain."
      Deininger M.H. , Trautmann K.
      Submitted (2000-08) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
      tissue: Glial tumor.
    9. 9.
      Del Galdo F. , Artlett C. , Jimenez S.A.
      Submitted (2006-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)
    10. 10.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT ARG-14
    11. 11.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
    12. 12.
      "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."
      Xie T. , Rowen L. , Aguado B. , Ahearn M.E. , Madan A. , Qin S. , Campbell R.D. , Hood L.
      Genome Res.13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT ARG-14
    13. 13.
      "Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region."
      Shiina S. , Tamiya G. , Oka A. , Inoko H.
      Submitted (1999-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    14. 14.
      "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
      Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    15. 15.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    16. 16.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Prostate.
    17. 17.
      "AIF-1 expression modulates proliferation of human vascular smooth muscle cells by autocrine expression of G-CSF."
      Chen X. , Kelemen S.E. , Autieri M.V.
      Arterioscler. Thromb. Vasc. Biol.24:1217-1222(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    18. 18.
      "Expression of allograft inflammatory factor-1 in T lymphocytes: a role in T-lymphocyte activation and proliferative arteriopathies."
      Kelemen S.E. , Autieri M.V.
      Am. J. Pathol.167:619-626(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH ACTIN;TISSUE SPECIFICITY
    19. 19.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBUNIT
    20. 20.
      "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
      Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-11;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    21. 21.
      "X-ray structures of the microglia/macrophage-specific protein Iba1 from human and mouse demonstrate novel molecular conformation change induced by calcium binding."
      Yamada M. , Ohsawa K. , Imai Y. , Kohsaka S. , Kamitori S.
      J. Mol. Biol.364:449-457(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 17-123 OF APOPROTEIN
    22. 22.
      "NMR structure of the human allograft inflammatory factor 1."
      Center for eukaryotic structural genomics (CESG)
      Submitted (2009-02) to the PDB data bank
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 2-147
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